Aya Sobhy Hashem, Salwa Atef Ganaa, Amal Said Elbendary and Ayman Hassan Fathy Abd El-Zaher
Background: Interleukin - 6 is found to be involved in various cancer types but countable studies has investigated its role in cancer lung.
Objectives: The purpose of this research was to assess Interleukin-6 levels in bronchoalveolar lavage (BAL) and serum of cases with cancer lung and cases with benign lung conditions, and to determine its diagnostic utility for cancer lung.
Subjects and Methods: This prospective interventional analytic study was conducted 40 cases at the Chest Department of Tanta University Hospitals. Cases were divided into two distinct groups: Group 1 comprised twenty individuals with bronchogenic carcinoma, while Group 2 comprised twenty individuals with non-malignant lung illnesses with established causes. All cases received a clinical examination, demographic information, and standard investigations. Using ELISA, the expression of interleukin-6 in BAL and serum was analysed.
Results: Interleukin-6 levels were elevated in the BAL and serum of cancer cases versus the control group. Interleukin-6 levels in BAL and serum were positively correlated with advanced clinical stages of cancer lung, as were Interleukin-6 levels in BAL and serum.
Conclusions: High BAL Interleukin-6 levels were associated with advanced clinical stage of cancer lung and correlated positively with serum Interleukin-6 levels. BAL Interleukin-6 was determined to be a molecular biomarker for cancer lung diagnosis and prognosis based on its high sensitivity and specificity in detecting lung carcinoma.
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