Vol. 3, Issue 1, Part A (2021)

Background: Asthma is a chronic inflammatory disorder of the airway. Eosinophil and Serum IgE being a marker of airway inflammation, can serve as a tool for assessing severity and response to treatment in asthma patients. The correlation of clinical assessment with various markers of airway inflammation in asthma is not well established in the Indian population. Present study correlates induced sputum eosinophil, blood eosinophil and Serum IgE count in assessing the clinical severity in bronchial asthma. Aims: To study the correlation of sputum eosinophil, absolute eosinophil count and Serum IgE in assessing the clinical severity of asthma. Methods: It was a cross sectional quantitative study, which was carried out between Feb 2020 to feb 2021. Total 70 asthmatics was selected which underwent history, examinations and spirometry, after written consent. Severity of asthma was assessed by clinical features and by FEV1 in spirometry. (as per GINA guidelines). After assessing the severity of Bronchial asthma all patient underwent Sputum examination for sputum eosinophil counts, blood sampling for Absolue eosinophil counts and Serum IgE levels. After that sputum eosinophil counts, absolute eosinophil counts and serum IgE levels were correlated with severity of Bronchial Asthma. Conclusion: Assessment of eosinophil count in sputum and blood, and serum IgE in blood are simple and inexpensive method that can show a direct measurement of airway inflammation. Thus it can help to identify specific phenotypes in asthmatic patients who are more responsive to steroids, which needs to be demonstrated in future studies. It could be the preferred method in routine practice in monitoring airway inflammation and guiding management.